Rabbit Anti-BACE antibody
Catalog Number : RS-92178
Quantity size : 0.1ml (dilute with pH 7.4 0.01 M PBS or antibody diluent )
background:
background:
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease.
Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein(APP) by
two proteases, one of which is the protein encoded by this gene. The encoded protein, a member
of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic
protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms
have been described for this gene. [provided by RefSeq].
Function:
Rabbit Anti-BACE antibody
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the
N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the
generation and extracellular release of beta-cleaved soluble APP, and a corresponding
cell-associated C-terminal fragment which is later released by gamma-secretase.
Specificity : Anti-BACE is a rabbit polyclonal antibody
specific for anti-BACE of RAT, mouse，Human ，chi
- use for western blotting,elisa,immunoprecipitation and immunohistochemistry
– Protein G affinity chromatography purification, purity :>95%
Isotype: IgGRabbit Anti-BACE antibody
mol wt: 51 kDa
Application :
– WB=1:100-500
– ELISA=1:500-1000
– IHC-P=1:100-500
– IHC-F=1:100-500
optimal dilutions/concentrations should be determined by the end user..
Storage: Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized
antibody is stable at room temperature for at least one month and for greater than a year
when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody,
the antibody is stable for at least six weeks at 2-4 ℃
Important Note: This product as supplied is intended for research use only, not for use in
human, therapeutic or diagnostic applications.
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