美國NovaBios瘧原蟲快速檢測試紙（美國進口）

廣州健侖生物科技有限公司

本公司為大家供應(yīng)各種進口品牌瘧疾（瘧原蟲）檢測試劑盒，包括美國的NovaBios、美國CORTEZ、美國BinaxNOW、韓國SD、廣州創(chuàng)侖等美國CDC品牌。主要包括膠體金、酶免、PCR等方法學(xué)。歡迎咨詢

非洲等熱帶國家工作用瘧疾（瘧原蟲）檢測試紙

泰國等熱帶疫情發(fā)生國家旅游用瘧疾（瘧原蟲）檢測試紙

惡性瘧原蟲、間日瘧原蟲、三日瘧原蟲、卵形瘧原蟲檢測試劑盒

進口瘧疾檢測卡、瘧原蟲檢測試劑盒、瘧疾抗原檢測試劑盒

美國NovaBios瘧原蟲快速檢測試紙（美國進口）

媒介按蚊對瘧原蟲的免疫 
按蚊(Anopheles)是瘧疾的傳播媒介，不但為瘧原蟲在蚊體內(nèi)的配子生植和孢子生植提供了必要的內(nèi)環(huán)境和相關(guān)因子，而且按蚊的免疫系統(tǒng)也對瘧原蟲的發(fā)育和繁殖發(fā)揮抑制作用。蚊吸血時，通常有大量的配子體隨血餐進入蚊胃，但是蚊胃內(nèi)的瘧原蟲受按蚊的免疫攻擊，只有約1/10～1/20的能發(fā)育成動合子，當(dāng)動合子穿過蚊胃上皮細(xì)胞后，只有極少數(shù)卵囊成熟，孢子生植產(chǎn)生大量的子孢子釋放到蚊血淋巴中，但能在唾液腺內(nèi)發(fā)育成感染性子孢子的也只有很少一部分。由此可見，按蚊的免疫系統(tǒng)能抑制瘧原蟲的發(fā)育。按蚊對瘧原蟲的殺滅作用主要是通過黑化包被反應(yīng)進行的，此外，受染按蚊產(chǎn)生的NO和抗菌肽也對瘧原蟲在蚊體內(nèi)的發(fā)育具有一定的抑制作用。
黑化包被反應(yīng)是一種體液性黑化反應(yīng)(humoral melanization)。與其它昆蟲一樣，按蚊的黑化反應(yīng)是由前酚氧化酶級聯(lián)反應(yīng)(prophenoloxidase cascade)介導(dǎo)引起的。通過激活前酚氧化酶活化酶，使前酚氧化酶轉(zhuǎn)變成有活性的酚氧化酶(phenoloxidase,PO)，然后，PO羥化單酚氧化酶并氧化雙酚氧化酶，產(chǎn)生大量的醌類中間產(chǎn)物聚合形成黑色素。這些黑色素協(xié)同具有細(xì)胞毒性的醌類中間產(chǎn)物沉積到入侵的病原體周圍，起到隔離殺死病原體的作用，即黑化包被反應(yīng)。
潛伏期(incubation period)，指瘧原蟲侵入人體到出現(xiàn)臨床癥狀的間隔時間，包括紅細(xì)胞外期原蟲發(fā)育的時間和紅細(xì)胞內(nèi)期原蟲經(jīng)幾代裂體增殖達(dá)到一定數(shù)量所需的時間。潛伏期的長短與進入人體的原蟲種株、子孢子數(shù)量和機體的免疫力有密切關(guān)系。惡性瘧的潛伏期為7~27天；三日瘧的潛伏期為18~35天；卵形瘧的潛伏期為11~16天；間日瘧的短潛伏期株為11~25天，長潛伏期株為6~12個月或更長。
對我國河南、云南、貴州、廣西和湖南等省志愿者進行多次感染間日瘧原蟲子孢子的實驗觀察，表明各地均兼有間日瘧長、短潛伏期2種類型，而且二者出現(xiàn)的比例有由北向南短潛伏期比例增高的趨勢。由輸血感染誘發(fā)的瘧疾，潛伏期一般較短。

美國NovaBios

Media Anopheles immunization against Plasmodium
Anopheles is the carrier of malaria, which not only provides the necessary internal environment and related factors for the parasite and spore reproduction of the parasite in the mosquitoes, but also the immune system of the Anopheles also suppresses the development and reproduction of the parasite effect. Mosquitoes, usually a large number of gametes with the blood meal into the mosquito, but the mosquitoes within the mosquito by Anopheles immune attack, only about 1/10 ~ 1/20 can develop into zygotes, when the zygotic wear After mosquito gastric epithelial cells, only a very small number of oocysts mature, spore reproduction produces a large number of sporozoites released into the mosquito hemolymph, but in the salivary gland development of infectious sporozoites are only a small part. Thus, the mosquito's immune system can inhibit the development of malaria parasites. The killing effect of Anopheles on Plasmodium is mainly through the blackening coating reaction. In addition, the NO and antimicrobial peptides produced by Anopheles dirus are also inhibited by the development of the parasite in mosquitoes.
The blackening coating reaction is a humoral melanization. As with other insects, the blackening reaction of Anopheles is mediated by the prophenoloxidase cascade. By activating the pre-phenol oxidase-activating enzyme, the phenolic oxidase is transformed into an active phenoloxidase (PO), and then the PO hydroxylates the mono-phenol oxidase and oxidizes the bisphenol oxidase to produce a large amount of quinone The product is polymerized to form melanin. These melanin co-cytotoxic quinone intermediates are deposited around the invading pathogen, isolating and killing pathogens, ie, blacking the coating.
The incubation period refers to the time required for malaria parasites to penetrate the human body to the onset of clinical symptoms, including the time of development of protozoan protozoa and the time required for protozoan protozoa to reach a certain number of times. The length of the incubation period is closely related to the number of protozoan species, the number of sporozoites and the immunity of the body. The latency of falciparum malaria was 7 to 27 days, the incubation period was 18 to 35 days, the latency of ovoid malaria was 11 to 16 days, the short latency of P. vivax was 11 to 25 days, and the long latency was 6 ~ 12 months or longer.
The experimental observation on the sporozoites of Plasmodium falciparum in China, such as Henan, Yunnan, Guizhou, Guangxi and Hunan, showed that there were two types of malaria and short latency, The proportion of the ratio from north to south short latency increased trend. Malaria is induced by transfusion infection, and the latency is generally shorter.

美國NovaBios

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【公司名稱】 廣州健侖生物科技有限公司
【市場部】    楊永漢

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【騰訊  】 2042552662
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號二期2幢101-103室