Description

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Specifications

Target Protein Phospho-Tau (Thr231)

Clonality Polyclonal

Storage/Stability -20°C/1 year

Application WB,ELISA

Recommended Dilution WB 1:500-1:2000

Concentration 1 mg/ml

Reactive Species Human,Mouse,Rat

Host Species Rabbit

Immunogen A synthesized peptide derived from human Tau around the phosphorylation site of Threonine 231

Specificity Phospho-Tau (Thr231) Antibody detects endogenous levels of Tau only when phosphorylated at Threonine 231

Purification The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Form Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt

Gene Name MAPT

Accession No. P10636

Alternate Names AI413597; AW045860; DDPAC; FLJ31424; FTDP 17; G protein beta1/gamma2 subunit interacting factor 1; MAPT; MAPTL; MGC134287; MGC138549; MGC156663; Microtubule associated protein tau; Microtubule associated protein tau isoform 4; Microtubule-associated protein tau; MSTD; Mtapt; MTBT1; MTBT2; Neurofibrillary tangle protein; Paired helical filament tau; Paired helical filament-tau; PHF tau; PHF-tau; PPND; PPP1R103; Protein phosphatase 1, regulatory subunit 103; pTau; RNPTAU; TAU; TAU_HUMAN; Tauopathy and respiratory failure, included;

促進(jìn)微管組裝和穩(wěn)定性，并可能參與神經(jīng)元極性的建立和維持。C末端結(jié)合軸突微管，而N末端結(jié)合神經(jīng)質(zhì)膜成分，這表明tau作為兩者之間的連接蛋白起作用。軸突極性由中心體定義的細(xì)胞體結(jié)構(gòu)域中的TAU/MAPT定位（在神經(jīng)元細(xì)胞中）預(yù)先確定。短亞型允許細(xì)胞骨架的可塑性，而較長的亞型可以優(yōu)先在其穩(wěn)定中發(fā)揮作用。

艾美捷磷酸化-Tau（Thr 231）抗體#GBS-ITA0919-100u規(guī)格：

目標(biāo)蛋白 磷酸Tau（Thr231）

克隆性 多克隆

儲存/穩(wěn)定性 -20°C/1 年

應(yīng)用 WB，酶聯(lián)免疫吸附法

推薦稀釋度 WB 1：500-1：2000

濃度 1毫克/毫升

反應(yīng)性物質(zhì) 人，老鼠，大鼠

寄主物種 兔

免疫原 一種衍生自人Tau的合成肽，圍繞蘇-氨酸231的磷酸化位點(diǎn)

特 異性 磷酸化-Tau抗體（Thr231）僅在蘇-氨酸231磷酸化時(shí)檢測Tau的內(nèi)源性水平

純化 該抗體來自純化的兔血清，通過磷酸化和非磷酸肽親和柱上的順序色譜進(jìn)行親和純化。

形式 兔IgG在磷酸鹽緩沖鹽水中，pH 7.4，150mM NaCl，0.02%疊-氮-化鈉和50%甘油。儲存在-20°C.自收到之日起可穩(wěn)定保存12個(gè)月

基因名稱 馬普特

藏品編號 P10636

細(xì)胞通路/類別 一抗多克隆抗體

蛋白質(zhì)分子量 78kDa

用法 僅供研究使用！不適用于診斷或治療程序